Have you seen others do it? That's a great starting point.
Also, I would recommend buying Pat Flynn's book, Will it Fly?
Hey Caleb - If you don't know it already, Cliff Ravenscraft's story may be helpful.
Here's a link http://podcastanswerman.com/blogworldnyctalk/
Thanks for sharing Alan that link Alan.
Caleb, it is important to know, that with my own personal experience, I allowed my podcast experience devoted to the tv show LOST, and a few other tv shows, to lead me into a business around podcast consulting/training.
I've known a few people who have generated "some income" from these types of podcasts. However, I haven't met anyone who makes a significant, full-tim, income from doing it.